January 15, 1493 – Christopher Columbus sets sail for Spain from Hispaniola, ending his first voyage to the New World.

February 15, 1493 – While on board the Niña, Christopher Columbus writes an open letter (widely distributed upon his return to Portugal) describing his discoveries and the unexpected items he came across in the New World.

March 4, 1493 – Explorer Christopher Columbus arrives back in Lisbon, Portugal, aboard his ship Niña from his voyage to what is now The Bahamas and other islands in the Caribbean.

March 15, 1493 – Christopher Columbus returns to Spain after his first trip to the Americas.

May 4, 1493 – Pope Alexander VI divides the New World between Spain and Portugal along the Line of Demarcation.

July 12, 1493 – Hartmann Schedel’s Nuremberg Chronicle, one of the best-documented early printed books, is published.

September 9, 1493 – Battle of Krbava field, a decisive defeat of Croats in Croatian struggle against the invasion by the Ottoman Empire.

November 3, 1493 – Christopher Columbus first sights the island of Dominica in the Caribbean Sea.

November 18, 1493 – Christopher Columbus first sights the island now known as Puerto Rico.

November 19, 1493 – Christopher Columbus goes ashore on an island he first saw the day before. He names it San Juan Bautista (later renamed Puerto Rico).

March 15, 1493 – Anne de Montmorency, Constable of France (d. 1567)

June 5, 1493 – Justus Jonas, German Protestant reformer (d. 1555)

September 28, 1493 – Agnolo Firenzuola, Italian poet (d. 1545)

October 14, 1493 – Shimazu Tadayoshi, Japanese warlord (d. 1568)

November 11, 1493 – Paracelsus, physician (d. 1541)