March 4, 1519 – Hernan Cortes arrives in Mexico in search of the Aztec civilization and their wealth.

April 21, 1519 – Hernán Cortés lands in Veracruz, Veracruz

June 28, 1519 – Charles V is elected Emperor of the Holy Roman Empire.

August 10, 1519 – Ferdinand Magellan’s five ships set sail from Seville to circumnavigate the globe. The Basque second in command Sebastian Elcano will complete the expedition after Magellan’s death in the Philippines.

August 15, 1519 – Panama City, Panama, is founded.

September 20, 1519 – Ferdinand Magellan sets sail from Sanlúcar de Barrameda with about 270 men on his expedition to circumnavigate the globe.

November 8, 1519 – Hernán Cortés enters Tenochtitlán and Aztec ruler Moctezuma welcomes him with a great celebration.

January 18, 1519 – Isabella Jagiełło, queen of Hungary (d. 1559)

February 5, 1519 – René of Châlon, (d. 1544)

February 17, 1519 – Francis, Duke of Guise, French soldier and politician (d. 1563)

March 31, 1519 – King Henry II of France (d. 1559)

April 13, 1519 – Catherine de' Medici, wife of Henry II of France (d. 1589)

May 27, 1519 – Girolamo Mei, Italian historian (d. 1594)

June 6, 1519 – Andrea Cesalpino, Italian philosopher and botanist (d. 1603)

June 12, 1519 – Cosimo I de' Medici, Grand Duke of Tuscany (d. 1574)

June 15, 1519 – Henry FitzRoy, 1st Duke of Richmond and Somerset, illegitimate son of King Henry VIII of England (d. 1536)

June 24, 1519 – Theodore Beza, French theologian (d. 1605)